EVALUATION OF THE NEUROPROTECTIVE EFFECTS OF HYDROETHANOLIC EXTRACT OF DIOSPYROS MESPILLIFORMIS TRUNK BARK (EBENACEA) ON DIAZEPAM-INDUCED AMNESIA IN MICE

Diospyros mespilliformis (DM) is a plant of the Ebonaceae family that commonly used in traditional medicine to treat epilepsy and schizophrenia. Radial arm mazes (RAM), Y mazes, novel object recognition test (NOR) were assess working reference memory mice. After different tests, hippocampus animals was separated for determination biochemical markers such as acetylcholinesterase (AchE), malondialdehyde (MDA), superoxide dismutase (SOD). The extract produced significant rise percentage alternation mice Y-maze test, time observe new at dose 50 mg/kg (p<0.01), discrimination index (p<0.001) all treated with compared negative control. result RAM showed decrease (p<0.05) number errors on 100 mg/kg. significantly decreased AchE activity, MDA concentration, increased SOD activity control group. These effects hydroethanolic DM would be related phenolic compounds quantified extract.